Expression of p16 in Sinonasal Undifferentiated Carcinoma (SNUC) Without Associated Human Papillomavirus (HPV)
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چکیده
منابع مشابه
Sinonasal Undifferentiated Carcinoma (SNUC): the Alberta experience and literature review
BACKGROUND Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy with often dismal outcomes. This study set to determine provincial and literature-wide survival outcomes based on treatment modality. METHODS Retrospective chart review of all SNUC patients in the province of Alberta from 1986-2010 was conducted. A review of the literature of SNUC patients was also performed. Patient/...
متن کاملSinonasal undifferentiated carcinoma.
PURPOSE The purpose of this paper is to discuss the treatment and outcomes for patients with sinonasal undifferentiated carcinoma. METHODS Review of the pertinent literature. RESULTS Most series contain a limited number of patients treated with various combinations of surgery, radiotherapy (RT), and chemotherapy. Follow-up periods for disease-free patients are sometimes relatively short. Th...
متن کاملSinonasal undifferentiated carcinoma: an update.
PURPOSE OF REVIEW Sinonasal undifferentiated carcinoma is a rare and extremely malignant tumor of the paranasal sinuses. Historically, treatment outcomes have been poor. This review presents recent data on the management of sinonasal undifferentiated carcinoma and examines treatment trends that may result in improved locoregional control and survival. RECENT FINDINGS Patients who receive aggr...
متن کاملLeptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma.
BACKGROUND Sinonasal undifferentiated carcinoma (SNUC) is an uncommon neoplasm characterized by local extension and an aggressive course. Treatment often includes a combination of chemotherapy, radiation therapy, and surgery, although the optimal strategy remains unclear. Here, we present the first reported case of leptomeningeal carcinomatosis from SNUC. METHODS AND RESULTS A 28-year-old man...
متن کاملFibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer.
BACKGROUND Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. METHODS One hundred twelve primary tumors (including squamous c...
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ژورنال
عنوان ژورنال: Head and Neck Pathology
سال: 2011
ISSN: 1936-055X,1936-0568
DOI: 10.1007/s12105-011-0285-8